A Study on the Evaluation and Examination of Orthostatic Hypotension in Type 2 Diabetes Patients Based on Lower Limb Muscle Mass A Controlled Study of Blood Pressure Variability Associated with Body Position Changes in Patients with Type 2 Diabetes Mellitus and Normal Subjects

Evaluation and investigation of orthostatic hypotension in Type 2 diabetes in terms of lower limb muscle mass: Comparative study of blood pressure variability associated with positional changes

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

JPRN

Registry ID

JPRN-jRCT1040230044

Enrollment

Registered

2023-06-24

Start date

2023-06-24

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Patients with type 2 diabetes Healthy Subjects

Interventions

None listed

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Type 2 Diabetes Mellitus: Patients with type 2 diabetes mellitus, aged 20 to under 80 years (both male and female), who are hospitalized for blood glucose control, scheduled for retinal surgery, or for diabetes education purposes from the date of approval to March 31, 2026. Subjects must provide written consent to participate in this study. Healthy Subjects: Healthy individuals, aged 40 to under 80 years (both male and female), without specific chronic diseases and without any impediments to daily life, who have undergone or are scheduled to undergo a blood test for Hemoglobin A1c (HbA1c: 4-6% range) within the past 2 months or within the next 2 months from the date of the orthostatic test for this study. Subjects must provide written consent to participate in this study.

Exclusion criteria

Exclusion criteria: Medications being taken (drugs affecting the autonomic nervous system, tranquilizers, psychostimulants, levodopa and other drugs for the treatment of Parkinson's disease, antihypertensive drugs, vasodilators, etc.) Persons deemed inappropriate as research subjects by the principal investigator

Design outcomes

Primary

Measure	Time frame
Type 2 Diabetes Mellitus:This is the relationship between blood pressure change during standing and muscle mass at admission, at discharge, and 3 months after discharge Healthy Subjects: 1st	—

Secondary

Measure	Time frame
Type 2 Diabetes Mellitus: Change in HbA1c at admission and 3 months after discharge Comparison of questionnaires on diabetes self-management at admission and 3 months after discharge Comparison of questionnaires on subjective symptoms on standing at admission, at discharge, and 3 months after discharge Cardiac output, heart rate, R-R interval Healthy subjects: muscle mass, blood pressure	—

Contacts

Public ContactQingbo Zhang

Nagoya University

zhang.qingbo.r9@s.mail.nagoya-u.ac.jp+81-90-3451-7956

Outcome results