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Neural responses to transcutaneous auricular vagus nerve stimulation in the nucleus of solitary tract, locus coeruleus and cerebral cortex

Neural responses to transcutaneous auricular vagus nerve stimulation in the nucleus of solitary tract, locus coeruleus and cerebral cortex

Status
Recruiting
Phases
Unknown
Study type
Interventional
Source
JPRN
Registry ID
JPRN-jRCT1040220145
Enrollment
35
Registered
2023-02-22
Start date
2024-09-04
Completion date
Unknown
Last updated
2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Healthy adults, expected effect

Interventions

Intervention type: Transcutaneous auricular vagus nerve stimulation Stimulation site: tragus, earlobe (control condition) Stimulation parameters: frequency 1-25 Hz, pulse width 100-500 microsecond Sti
transcutaneous auricular vagus nerve stimulation, taVNS

Sponsors

Harada Tokiko
Lead Sponsor
Ohira Hideki
Collaborator

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: 1. Healthy adults who do not meet the exclusion criteria 2. right-handed 3. Japanese native speakers 4. Those who wish to participate in the research, fully understand the content of the research and have obtained written consent

Exclusion criteria

Exclusion criteria: 1. Persons who have an interest in the principal investigator or co-investigator (e.g., graduate school students, students taking classes, etc.) 2. People with metal objects such as heart, nerve pacemakers, artery clips, etc. 3. People who have had a metal clip inserted due to an injury (because there is a possibility of residual metal in the body) 4. People who have a history of metal processing (because there is a possibility of residual metal in the body) 5. Those who are wearing orthodontic appliances or have metal implants (fillings and crowns are acceptable even with metal) 6. Persons wearing non-removable metal (eyelash extensions, nail parts, wigs, etc.) 7. people who have had brain surgery 8. People who have or have a history of mental illness 9. People with a history of claustrophobia or fear of the dark 10. Those who have a history of hernia, etc. and cannot maintain the same posture for a long time 11. Persons with visual impairment that interferes with daily life (excluding cases where the use of glasses or contact lenses does not interfere with daily life) or hearing impairment 12. People taking drugs (cold remedies, drugs that control the action of neurotransmitters, etc.) 13. People who cannot use both hands due to injury (because they will be pressing buttons in the experiment) 14. pregnant or possibly pregnant

Design outcomes

Primary

MeasureTime frame
Changes in brain activity measured by functional magnetic resonance imaging during transcutaneous auricular vagus nerve stimulation

Secondary

MeasureTime frame
Changes in heart rate and pupillary diameter during transcutaneous auricular vagus nerve stimulation

Contacts

Public ContactTokiko Harada

Nagoya University

tokikoh@gmail.com+81-52-789-2223

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026