Chronic kidney disease Chronic kidney disease
Conditions
Interventions
The patient is required to follow a normal chronic kidny disease dietary treatment with the addition of 50 g of sake lees per day for 8 weeks.
Sake lees
Sponsors
Tokumaru Toshiaki
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1) Patients attending the outpatient department of nephrology at Kanazawa University Hospital 2) Patients whose most recent eGFR within 3 months prior to enrollment was between 15 mL/min/1.73 m2 and 59 mL/min/1.73 m2 3) Patients who meet the diagnostic criteria for chronic kidney disease 4) Patients whose age at the time of consent is 20 years or older 5) Patients whose performance status (ECOG) at the time of consent is 0 6) Patients who have given their free written consent to participate in this clinical trial after obtaining sufficient informed consent
Exclusion criteria
Exclusion criteria: 1) Patients on dialysis therapy 2) Patients after renal transplantation 3) Patients with cancer 4) Patients with Body Mass Index less than 16 5) Patients with primary and secondary immunodeficiency 6) Patients with inflammatory bowel disease 7) Patients with hepatic impairment or hepatic dysfunction 8) Patients who routinely take antibacterial drugs 9) Patients who routinely consume sake lees 10) Patients with alcohol intolerance 11) Patients with a history of antimicrobial use within the past 4 weeks from the time of study entry 12) Patients with a history of alcohol dependence 13) Patients who are deemed by the physician to be inappropriate to participate in this study
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Amount of change in blood indoxyl sulfate concentration before and 8 weeks after intake of sake lees. | — |
Secondary
| Measure | Time frame |
|---|---|
| Blood p-cresyl sulfate concentration Blood D-serine and D-alanine concentrations Fecal uremic substance concentration Fecal short-chain fatty acid concentration Fecal pH Fecal D-serine and D-alanine concentrations Metagenomic analysis of fecal flora Constipation score (CSS) Constipation and quality of life score (PAC-QOL) Urinary protein/creatinine ratio Urinary MCP-1 and KIM-1 levels Daily salt intake estimated from spot urine Urinary pH | — |
Contacts
Public ContactToshiaki Tokumaru
Kanazawa University Hospita
Outcome results
None listed