CKD patients renal functional reserve
Conditions
Interventions
Creatinine clearance is measured amang infusion of 2h an amino acid solution (AMIZET B, TERUMO) at the 80ml/min to healthy volunteer or patients with chronick kidney disease.
Sponsors
Isobe Shinsuke
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Healthy volunteer 1. 20-80 years old 2. Individuals without CKD 3. Individuals with written informed consent CKD patients 1. 20-80 years old 2. eGFR < 60ml/min/1.73m2, or evidence of proteinuria and/or hematuria 3. CKD patients with written informed consent
Exclusion criteria
Exclusion criteria: Health volunteer 1. Those who compricated or are being treater other disease 2. Pregnant , lactating, or menstruating women 3. Those who are judged by the principal investigator or the investigator to be unsuitable for participation in the research CKD patients 1. Patients requiring hemodialysis or peritoneal dialysis 2. Sever acidosis 3. Congestive heart failure 4. Hyponatremia 5. Pregnant , lactating, or menstruating women 6. Treated with SGLT2 inhibitor, diuretics, or renin-angiotensin inhibitors. 7. Those who are judged by the principal investigator or the investigator to be unsuitable for participation in the research
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| We compare the correlation between the renal functional reserve which evaluated the conventional method and the simple method, for healthy volunteer and patients with chronic kidney disease. | — |
Secondary
| Measure | Time frame |
|---|---|
| Multiple linere regression analyses will be performed to evaluate the relationship the renal functional reserve using the simplified method and that evaluating the conventional method. | — |
Contacts
Public ContactShinsuke Isobe
Hamamatsu University School of Medicine
Outcome results
None listed