CLEAR Study

CLinical Effects of PeriodontAl Treatment on Low-density Lipoprotein Cholesterol Reduction in Patients with Coronary Artery Disease: A Multicenter, Randomized Controlled Trial - CLEAR Study

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-jRCT1032260041

Enrollment

Registered

2026-04-13

Start date

2026-04-13

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Coronary artery disease, periodontal disease Periodontal Disease Treatment, LDL-C

Interventions

Non-surgical periodontal treatment

D010510

Treatment

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Patients with coronary artery stenosis who also have periodontal disease

Exclusion criteria

Exclusion criteria: Patients undergoing periodontal treatment, patients requiring urgent therapeutic intervention, patients with familial hypercholesterolemia, patients with secondary hypercholesterolemia, etc.

Design outcomes

Primary

Measure	Time frame
Absolute change in LDL-C (mg/dL) from baseline to 16 weeks after periodontal treatment	—

Secondary

Measure	Time frame
Change in blood pressure (mmHg), change in HbA1c value (%), TG (mg/dL), HDL-C (mg/dL), inflammatory markers, etc.	—

Contacts

Public ContactKozo Okada

Yokohama City University Medical Center

kokada2@yokohama-cu.ac.jp+81-452615656

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026