Malignant glioma (suspected) located near the motor cortex or corticospinal tract
Conditions
Interventions
During brain tumor resection, cortical and subcortical stimulation will be performed using the Neuromaster built-in automatic threshold measurement function in addition to conventional intraoperative
D005909
glioblastoma
Sponsors
Miki Syunichiro
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1) Male and female patients aged 18 years or older. 2) Patients scheduled to undergo craniotomy for resection of an intra-axial brain tumor suspected to be malignant glioma. 3) Patients in whom preoperative MRI, tractography, or other imaging studies indicate that the tumor is located within or in close proximity to the primary motor cortex and/or the corticospinal tract. 4) Patients with a general condition adequate to allow intraoperative neurophysiological monitoring, including motor evoked potential (MEP) monitoring. 5) Patients undergoing surgery in the supine position. 6) Patients who have provided written informed consent, either by the patient themselves or by a legally authorized representative, after receiving a full explanation of the study and demonstrating sufficient understanding, based on their own free will.
Exclusion criteria
Exclusion criteria: 1) Participants who are deemed unable to undergo general anesthesia and/or intraoperative neurophysiological monitoring due to severe comorbidities (cardiac disease, hepatic failure, renal failure and so on). 2) Participants with neurological disorders that make intraoperative MEP recording difficult or unreliable. 3) Participants with muscle strength of 3 or lower on the Manual Muscle Test (MMT) in the upper and/or lower extremities. 4) Participants who are pregnant or for whom pregnancy cannot be ruled out. 5) Participants with implanted medical devices that may be affected by electrical stimulation (for example pacemakers). 6) Participants deemed inappropriate for participation in this study by the principal investigator or (sub)investigators.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Comparison of the threshold stimulation intensity identified by the threshold-measurement program and the minimum stimulation intensity required to elicit motor evoked potentials using the conventional subcortical stimulation method | — |
Secondary
| Measure | Time frame |
|---|---|
| Comparison between stimulation thresholds and the distance to the corticospinal tract estimated from postoperative MRI | — |
Contacts
Public ContactHiroki Karita
University of Tsukuba Hospital
Outcome results
None listed