Resectable liver cancer
Conditions
Interventions
Test equipment group: Circulation monitoring during surgery will be performed using an HPI system consisting of a dedicated sensor (Acumen IQ sensor) and monitor (HemoSphere).
Standard equipment group
Sponsors
Ishikawa Seiji
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1) Patients aged 18 years or older and 80 years or younger at the time of obtaining consent 2) Patients diagnosed with liver cancer at the time of obtaining consent 3) Patients scheduled to undergo liver resection under general anesthesia 4) Inpatients 5) Patients who have the capacity to consent and can provide written consent of their own free will 6) Patients with ASA PS 1 to 3 7) Patients who the principal investigator (subinvestigator) judges to be able to appropriately evaluate the efficacy and safety of this study after considering the inclusion and exclusion criteria
Exclusion criteria
Exclusion criteria: 1) Patients who cannot undergo epidural anesthesia 2) Patients for whom invasive blood pressure monitoring is contraindicated 3) Patients with severe cardiac disease (left ventricular ejection fraction less than 40%) or pulmonary disease (forced expiratory volume in 1 second less than 40%) 4) Patients undergoing renal replacement therapy, including hemodialysis 5) Patients with atrial fibrillation 6) Patients with moderate or severe aortic or mitral valve stenosis or regurgitation 7) Pregnant women or women who may be pregnant 8) Breastfeeding women 9) Other patients who the principal investigator (subinvestigator) deems inappropriate to be study subjects
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Time-weighted average of hypotension (mean blood pressure < 65mmHg) during surgery | — |
Secondary
| Measure | Time frame |
|---|---|
| 1) Number of hypotension events (mean blood pressure < 65mmHg) during surgery (hypotension lasting for 1 minute or more is counted as 1 event) 2) Total time of hypotension (mean blood pressure < 65mmHg) during surgery (intraoperative hypotension duration) (events lasting less than 1 minute are not taken into account) 3) Average time per event of hypotension (mean blood pressure < 65mmHg) during surgery (mean intraoperative hypotension duration) 4) Percentage of time of hypotension (mean blood pressure < 65mmHg) to total monitoring time (from start of circulatory monitoring to end of anesthesia) 5) Area under the curve below the hypotension threshold (65mmHg) when the vertical axis is blood pressure and the horizontal axis is monitoring time 6) Incidence rate of acute kidney injury (KDIGO criteria) occurring within 72 hours after surgery | — |
Contacts
Public ContactSeiji Ishikawa
Juntendo University, Juntendo Hospital
Outcome results
None listed