Plasma oxytocin levels in women during labor with or without epidural analgesia, and study of perinatal mental health

Plasma oxytocin levels in women during labor with or without epidural analgesia : a comparative study, and study of perinatal mental health

Status

Recruiting

Phases

Early Phase 1

Study type

Observational

Source

JPRN

Registry ID

JPRN-jRCT1032240725

Enrollment

100

Registered

2025-03-10

Start date

2025-03-10

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Pregnancy

Interventions

None listed

Eligibility

Sex/Gender

Female

Inclusion criteria

Inclusion criteria: The subjects were women who pregnant aged 20 years or older. Among them, those who chose to give birth naturally were classified as the "natural labor group," and those who chose epidual analgesia were classified as the "epidual anaigesia group."

Exclusion criteria

Exclusion criteria: Women with endocrine disorders were excluded. In addition, women who induced labor and accelerated labor or cesarean section before blood sampling was completed twice during labor were excluded from the study.

Design outcomes

Primary

Measure	Time frame
Samples are plasma oxytocin, and psychological measures Oxytocin measurement plan Measurements will be taken at six locations. Phase1 are blood samples taken at late pregnancy, Phase2.3 are twice during labor, Phase4 are first day after labor, Phase5 are 3 or 4 days after labor, and Phase6 are 1 month after labor. Phase2.3 are blood sample was taken when before starting epidual anaigesia and 60 minutes later after starting epidual anaigesia at "epidual anaigesia group. At "natural birth group" was taken when labor bigin with cervix is between 3 to 5 cm open, and 60 minutes later after Phase2. 7 to 14ml blood samples were collected and promptly centrifuged to separate the plasma components, which were then frozen at or below minus 80 degrees Celsius. On the day of collection. Blood analysis will be performed at a later date using an ELISA kit. Psychological measures "Parental readiness" and "Japanese Wijma Delivery Expectancy" will be measured at the late pregnancy. "EPDS Edinburgh Postnatal Depression Scale" and "Bonding mensure" will be measured 3 or 4 days and 1 month after labor.	—

Measure

Time frame

Samples are plasma oxytocin, and psychological measures Oxytocin measurement plan Measurements will be taken at six locations. Phase1 are blood samples taken at late pregnancy, Phase2.3 are twice during labor, Phase4 are first day after labor, Phase5 are 3 or 4 days after labor, and Phase6 are 1 month after labor. Phase2.3 are blood sample was taken when before starting epidual anaigesia and 60 minutes later after starting epidual anaigesia at "epidual anaigesia group. At "natural birth group" was taken when labor bigin with cervix is between 3 to 5 cm open, and 60 minutes later after Phase2. 7 to 14ml blood samples were collected and promptly centrifuged to separate the plasma components, which were then frozen at or below minus 80 degrees Celsius. On the day of collection. Blood analysis will be performed at a later date using an ELISA kit. Psychological measures "Parental readiness" and "Japanese Wijma Delivery Expectancy" will be measured at the late pregnancy. "EPDS Edinburgh Postnatal Depression Scale" and "Bonding mensure" will be measured 3 or 4 days and 1 month after labor.

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Contacts

Public ContactKonami Kato

Juntendo University Nerima Hospital

k.kato.qo@juntendo.ac.jp+81-3-5923-3111

Outcome results