Evaluation of neuroplasticity and biomarker after neurorehabilitation for Parkinson's disease

Evaluation of neuroplasticity and molecular profile of plasma exosomes after neurorehabilitation for Parkinson's disease

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-jRCT1032240550

Enrollment

Registered

2024-12-13

Start date

2024-01-12

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Parkinson's disease Parkinson's disease, exosomes, functional MRI, extracellular vesicles

Interventions

Compared to regular rehabilitation aimed at maintaining daily life and ADL, the rehabilitation in this study focuses on active aerobic exercise, mainly in the sitting and standing positions. Meanwhile

D000066530

Neurorehabilitation

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1) PD patients diagnosed by a neurologist based on the UK Parkinson's Disease Society Brain Bank 2) PD patients currently attending our outpatient clinic 3) Yahr severity level 3 or less

Exclusion criteria

Exclusion criteria: 1) Patients under 20 years of age 2) Patients with moderate or higher cognitive function (MMSE < 24) 3) Patients with contraindications for MRI due to pacemakers, metal in the body, or claustrophobia 4) Patients for whom aerobic exercise is deemed inappropriate due to unstable hypertension, diabetes, cerebrovascular disease, heart disease (ischemic heart disease, arrhythmia, heart failure, etc.), peripheral arterial occlusive disease, orthostatic hypotension, pulmonary disease, etc. 5) Patients with neurological or orthopedic diseases who cannot undergo rehabilitation using stretching or an exercise bike 6) Patients with mental disorders such as depression diagnosed by a psychiatrist, or those with significant mental symptoms

Design outcomes

Primary

Measure	Time frame
Neuroplasticity determined by comparing head MRI before and after neurorehabilitation and molecular mechanisms related to neuroplasticity determined by integrated analysis of changes in blood exosome profiles	—

Secondary

Measure	Time frame
1) Neuroplasticity obtained by comparing head MRI before and after neurorehabilitation 2) Changes in blood exosome profile (microRNA, mRNA, protein, metabolites, etc.) 3) Changes in PD-related evaluation items HDS-R, MMSE UPDRS part I, II, III, IV Beck Depression Scale Wearing-off Questionnaires19 Sit to stand-5 Time up and go test Functional reach test Mini-Bestest Falls efficacy scale-International	—

Measure

Time frame

1) Neuroplasticity obtained by comparing head MRI before and after neurorehabilitation 2) Changes in blood exosome profile (microRNA, mRNA, protein, metabolites, etc.) 3) Changes in PD-related evaluation items HDS-R, MMSE UPDRS part I, II, III, IV Beck Depression Scale Wearing-off Questionnaires19 Sit to stand-5 Time up and go test Functional reach test Mini-Bestest Falls efficacy scale-International

—

Contacts

Public ContactYuto Morishima

University of Yamanashi

ymorishima@yamanashi.ac.jp+81-55-273-9896

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026