Patients undergoing surgery under general anesthesia
Conditions
Interventions
Patients will be randomized to either the remimazolam group or the propofol group, and the method of anesthesia maintenance will be determined.
Sponsors
Itaya Tomoaki
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1) Patients aged 65 years or older at the time of obtaining consent (pre-operative consultation) 2) Cases with an American Society of Anesthesiologists (ASA) pre-anesthetic risk assessment of less than 4 (ASA classification: 1: No organic, physiological, biochemical, or psychiatric abnormalities. 2: Mild to moderate systemic impairment. 3: Severe systemic impairment. 4: Severe systemic disease that is life-threatening and may not be curable even with surgery. 5: Critically ill.) 3) Patients who have received a thorough explanation of participation in this study at the pre-operative consultation, fully understood the information, and provided written consent of their own free will.
Exclusion criteria
Exclusion criteria: 1) Patients with a history of allergy to muscle relaxants 2) Cases with severe systemic complications (American Society of Anesthesiologists pre-anesthetic risk assessment of 4 or higher) 3) Patients with neuromuscular diseases 4) Patients taking medications that may affect the effectiveness of muscle relaxants 5) Others whom the principal investigator deems unsuitable as research subjects 6) Individuals who have refused to participate in this study
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Time to the TOF ratio of 90% | — |
Secondary
| Measure | Time frame |
|---|---|
| Time to the maximum onset of muscle relaxation effect Time to reach 10%, 20%, 30%, 40%, 50%, 60%, 70%, 80% T1, T2, and TOF ratios (process of recovery from moderate muscle relaxation) T1 height at each TOF recovery point | — |
Contacts
Public ContactTomoaki Itaya
Nihon University School of Medicine Itabashi Hospital
Outcome results
None listed