Patients undergoing general anesthesia General Anesthesia
Conditions
Interventions
This study compares propofol- and remimazolam-based anesthesia with remifentanil in a randomized design.
D007427, D015742, D000077208, C522201
Propofol, Remimazolam, Remifentanil, General anesthesia.
Sponsors
Ogawa Yojiro
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Healthy adult aged 18-65 years who consented to participate were included in this study. 2. Subjects who received a sufficient explanation during the preoperative assessment and provided voluntary written informed consent with full understanding were included. 3. Patients with an American Society of Anesthesiologists (ASA) physical status of II or lower were included.
Exclusion criteria
Exclusion criteria: 1. Patients who refuse to participate in the study. 2. Patients deemed unsuitable as research subjects by the principal investigator. 3. Patients with an American Society of Anesthesiologists (ASA) physical status of III or higher. 4. Patients taking oral medications that affect the autonomic nervous system. 5. Patients with autonomic dysfunction, hypertension, diabetes mellitus, or cerebrovascular disease. 6. Patients receiving epidural anesthesia or a peripheral nerve block in addition to general anesthesia. 7. Patients with a history of allergy to general anesthetics or to foods such as dairy products or soybeans.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Autonomic circulatory regulation, Cerebral autoregulation. | — |
Secondary
| Measure | Time frame |
|---|---|
| Hemodynamic, respiratory condition, autonomic nereous acitivity, cerebral circulation. | — |
Contacts
Public ContactYojiro Ogawa
Nihon University School of Medicine
Outcome results
None listed