Comparison of pain relief methods after wisdom tooth extraction

A Randomized Controlled Trial Comparing Postoperative Analgesic Effects of Ultrasound-Guided Lateral Pterygoid Muscle Block versus Local Anesthetic Wound Infiltration Following Impacted Wisdom Tooth Extraction (ALPINE Study: Alveolar Lateral Pterygoid Injection versus Normal Exposure) - ALPINE Study

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-jRCT1031250592

Enrollment

Registered

2025-12-23

Start date

2025-12-23

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Impacted wisdom tooth Impacted wisdom tooth, Third molar, Impacted tooth

Interventions

Intervention group: Ultrasound-guided lateral pterygoid muscle block (Popscaine: levobupivacaine 0.25% 10mL) combined with local anesthetic wound infiltration Control group: Local anesthetic wound inf

A06.00.050.950

Lateral pterygoid muscle block, Ultrasound-guided, Nerve block, Local anesthesia

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. Adults aged 18 years or older 2. Scheduled for impacted wisdom tooth extraction with ASA-PS classification 1 or 2 3. Capable of providing written informed consent and communicating in Japanese

Exclusion criteria

Exclusion criteria: 1. History of allergy to amide-type local anesthetics 2. Pregnancy or breastfeeding 3. Severe hepatic dysfunction (Child-Pugh class B or higher) 4. Severe renal dysfunction (eGFR less than 30mL/min/1.73m2) 5. Anticoagulation therapy with PT-INR exceeding therapeutic range

Design outcomes

Primary

Measure	Time frame
Pain intensity at rest at 6 hours postoperatively (Numerical Rating Scale: NRS 0-10)	—

Secondary

Measure	Time frame
1. Postoperative pain assessment (NRS 0-10): at extubation, 2 hours, 6 hours, 21:00 (before sleep), 07:00 (next morning), and 10:00 (next day), at rest and during mouth opening 2. Time to first rescue analgesic administration 3. Total analgesic consumption until 10:00 the next day	—

Contacts

Public ContactKeisuke Nakazawa

Nihon University School of Medicine

nakazawa.keisuke@nihon-u.ac.jp+81-3-3972-8111

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026