Comparing the Incidence of Postoperative Headache Between Propofol and Sevoflurane for Maintenance of Anesthesia

A Single-Center Randomized Controlled Trial Comparing the Incidence of Postoperative Headache Between Propofol and Sevoflurane for Maintenance of Anesthesia

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-jRCT1031250112

Enrollment

120

Registered

2025-05-20

Start date

2025-05-20

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Patients undergoing elective surgery under general anesthesia

Interventions

Anesthesia will be maintained with either propofol or sevoflurane according to randomized allocation.

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Patients aged 18 to 70 years old who are scheduled for surgery and will undergo general anesthesia

Exclusion criteria

Exclusion criteria: 1) Patients with contraindications to the administration of propofol or sevoflurane 2) Patients with ASA classification of class 4 or higher, which is the general condition classification of the American Society of Anesthesiologists 3) Patients undergoing neurosurgery, spinal surgery, or head and neck surgery 4) Patients who may leave the operating room while intubated 5) Patients for whom the surgeon has specified or requested a general anesthesia method 6) Pregnant women

Design outcomes

Primary

Measure	Time frame
Presence of postoperative headache	—

Secondary

Measure	Time frame
Evaluate the severity of postoperative headache in 4 stages. Occurence of Postoperative nausea and vomit.	—

Contacts

Public ContactAya Higurashi

Yokohama City University Hospital

higurashi.aya.sc@yokohama-cu.ac.jp+81-45-787-2800

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026