Sepsis Sepsis
Conditions
Interventions
To compare the achievement of PK/PD targets (50%T>MIC or 100%T>MIC) for the two dosing regimens in patients receiving intermittent bolus and continuous infusion meropenem for sepsis.
Sponsors
Ohbayashi Masayuki
Eligibility
Inclusion criteria
Inclusion criteria: 1) Patients with sepsis or septic shock diagnosed by the Department of Emergency Medicine or the Department of Intensive Care at Showa University Hospital and scheduled to be administered or on meropenem at the time of admission 2) Patients with eGFR more than 85 mL/min 3) Patients who are 18 years of age or older at the time consent is obtained (4) Patients who have obtained written consent to participate in this study from the individual or surrogate
Exclusion criteria
Exclusion criteria: 1) Patients receiving renal replacement therapy 2) Patients with massive bleeding 3) Pregnant women 4) Patients who are judged to be ineligible as subjects by the primary doctor 5) Patients receiving valproate natrium, a contraindication to study drug administration 6) Patients with a history of hypersensitivity to any component of the study drug
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The achievement of PK/PD targets (50%T>MIC or 100%T>MIC) | — |
Contacts
Public ContactMasayuki Ohbayashi
Showa University School of Pharmacy
Outcome results
None listed