A multicenter prospective observational study on the prevention or suppression of progress of hemophilic arthropathy in hemophilia patients with inhibitors undergoing prophylaxis of Byclot.

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

JPRN

Registry ID

JPRN-jRCT1031240268

Enrollment

Registered

2024-08-09

Start date

2024-07-11

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Hemophilia A/B inhibitor

Interventions

None listed

Eligibility

Sex/Gender

Male

Inclusion criteria

Inclusion criteria: 1) hemophilia Patients with inhibitors who are undergoing prophylaxis with Byclot(regardless of age) 2) Patients who have given written consent to this study from themselves or their legal guardian

Exclusion criteria

Exclusion criteria: 1) Patients whose joints cannot be evaluated 2) Patients with a history of joint surgery within the past 6 months from the date of informed consent 3) Patients judged to be inappropriate to participate in this study by the principal investigator

Design outcomes

Primary

Measure	Time frame
1) Joint function evaluation by Haemophilia Jpoint Health Score (HJHS) (Changes in HJHS scores over time from the start to 3 years later)	—

Secondary

Measure	Time frame
1) Changes in joint image evaluation (X-ray:Pettersson score, ultrasound: HEAD-US score) over time . 2) Changes in annual bleeding rate (ABR) and annual joint bleeding rate (AjBR) over time. 3) Clinical test values: APTT, PT, FVIII activity and FVIII inhibitor titer for hemophilia A inhibitor patients, FIX activity and FIX inhibitor titer changes over time for hemophilia B inhibitor patients.	—

Contacts

Public Contacttsuyoshi hagiwara

Ogikubo hospital

thagi@tokyo-med.ac.jp+81-3-3399-1101

Outcome results