Post Surgical Pain at Cardiovascular surgery case with median sternotomy
Conditions
Interventions
Two types of sternal fasciocutaneous surface blocks performed near the sternum are performed and the blood local anesthetic concentration is measured at a defined time after injection of the local ane
Sponsors
Nakazawa Keisuke
Eligibility
Inclusion criteria
Inclusion criteria: 1) Adults 20 years of age or older 2) Those who fall under BMI 18.5 to 25.0 kg/m2 3) Patients with American Society of Anesthesiologists Pre-Anesthesia Risk Assessment (ASA-PS) 3 or less (ASA-PS Classification 1: No organic, biochemical or psychiatric abnormalities. Classification 2: Mild to moderate systematic impairment. Classification 3: Severe systematic disorder. Classification 4: Severe, life-threatening systemic disorders that cannot be cured by surgery (Classification 5: Dying). Classification 5: Dying.) 4) Persons who give written consent to participate in the research.
Exclusion criteria
Exclusion criteria: 1) Patients who do not meet the above selection criteria 2) Patients allergic to amide-type local anesthetics 3) Patients on anticoagulation therapy with PT-INR (Prothrombin Time International Normalized Ratio) > 1.2 or on dual anti-platelet therapy (DAPT), excluding biaaspirin monotherapy and prophylactic low molecular weight heparin therapy 4) Patients with any of the contraindications listed in the package insert. 5) Patients with moderate to severe hepatic dysfunction 6) Patients with arrhythmia requiring pacemaker insertion 7) Patients who meet all of the above selection criteria and none of the above exclusion criteria. 8) Patients who have refused to participate in this study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Determine the maximum blood concentration of local anesthetics, C max, and the time to reach the maximum blood concentration, Tmax (min), from the values of ropivacaine blood concentration at 5min, 10min, 15min, 30min, 45min, 60min, 90min, and 120 minutes after nerve block | — |
Secondary
| Measure | Time frame |
|---|---|
| Intubation time in the intensive care unit, post-extubation patient pain score VAS or NRS (2 hours, 6 hours, morning after surgery, 24 hours after extubation), record of analgesic use, presence of PONV, vital signs on leaving the operating room (max/min/average blood pressure, respiratory rate, pulse rate), and other information obtained from electronic anesthesia records Patient information and treatment details, number of cases requiring additional prescriptions for rescue analgesia (NSAIDs, weak opioid analgesics) in the intensive care unit, and time since awake extubation when the additional analgesia was requested. | — |
Contacts
Public ContactKeisuke Nakazawa
Nihon University School of Medicine Itabashi Hospital
Outcome results
None listed