milk allergy Food allergy
Conditions
Interventions
Sublingual immunotherapy with skimmed milk powder
Sublingual Immnotherapy
Sponsors
Takanori Imai
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Persons who meet all of the following criteria are eligible for selection. 1) Patients with obvious cow's milk allergy. *Obvious cow's milk allergy is defined as an immediate objective positive symptom (e.g. extensive urticaria, wheezing, coughing, dyspnoea, vomiting, diarrhoea, shock) with a threshold of less than 3 mL of milk in a food oral load test within 3 months of study initiation. 2) Patients who are eligible for sublingual immunotherapy at the start of the study.
Exclusion criteria
Exclusion criteria: 1) Patients with poorly controlled atopic dermatitis or bronchial asthma 2) Patients with serious or potentially study-affecting diseases of the circulatory system, cranial nerves, nephrology and urinary system, hepatobiliary and pancreatic-gastrointestinal tract, etc. 3) Other patients deemed unsuitable as subjects by the principal investigator.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Negative rate of 25 mL oral challenge test (2nd time) | — |
Secondary
| Measure | Time frame |
|---|---|
| Negative rate of 25 mL (1st) challenge test, rate of change in objective indicators (peripheral blood eosinophil count, serum total IgE, serum antigen-specific IgE (milk, casein, alpha gamma albumin, beta gamma globulin), antigen-specific IgG1,4, Binding-Avidity (milk), skin prick test (milk) ), safety assessment (incidence of adverse events (escalation phase, maintenance phase), adherence | — |
Contacts
Public ContactImai Takanori
Showa University school of Medicine
Outcome results
None listed