Patients undergoing general anesthesia
Conditions
Interventions
The sedative of choice is remimazolam, sevoflurane, or propofol, depending on the envelope method. Blood samples are drawn during general anesthesia.
Sponsors
Takagi Shunichi
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1) Patients over 65 years 2) Patients with American Society of Anesthesiologists physical status classification 1-3. 3) Patients who receive written informed consent.
Exclusion criteria
Exclusion criteria: 1. Patients with a history of allergy to muscle relaxants or antagonists 2. Patients with severe complications 3. patients with neuromuscular disease 4. Patients taking medications that may affect the effect of muscle relaxation. 5. Patients who are deemed inappropriate as research subjects by the principal investigator 6. Patients who refuse to participate in the study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| PTC appearance time in remimazolam, sevoflurane, and propofol groups | — |
Secondary
| Measure | Time frame |
|---|---|
| T1 and T2 appearance time in sevoflurane, propofol, and remimazolam groups, and time to 100% TOF ratio after sugammadex administration. PTC, and rocuronium-rocuronium protein binding rate in blood at T1 and T2 appearance | — |
Contacts
Public ContactHanae Sato
Nihon University Itabashi Hospital
Outcome results
None listed