Effects of GHRP-2 test on hormone secretion kinetics

A single-center prospective observational study of hormone secretion dynamics in the GHRP-2 test

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

JPRN

Registry ID

JPRN-jRCT1031230664

Enrollment

Registered

2024-02-28

Start date

2024-02-20

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Adult growth hormone deficiency Adult growth hormone deficiency

Interventions

None

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Patients with suspected adult growth hormone deficiency who will receive GHRP-2 at Kitasato University Hospital from the date of approval by the head of the research institute to September 30, 2026.

Exclusion criteria

Exclusion criteria: 1) severe obesity (BMI 35 kg/m2 or more) 2) Patients under 18 years old (not intended for pediatric patients) 3) Patients with contraindications to GHRP-2 (GHRP-100 for Injection) 4) Diabetes mellitus

Design outcomes

Primary

Measure	Time frame
Comparing the values of glucose metabolism-related hormones (GH, ACTH, cortisol, insulin, glucagon, GLP-1, GIP, and blood glucose levels) before and after GHRP-2 loading	—

Secondary

Measure	Time frame
The amount of change in GH levels before and after GHRP-2 administration and the amount of each hormone related to glucose metabolism (GH, ACTH, cortisol, insulin, glucagon, GLP-1, GIP, and blood glucose) will be compared for each disease. To verify whether there is a correlation between the change in GH levels before and after GHRP-2 administration and each hormone related to glucose metabolism (GH, ACTH, cortisol, insulin, glucagon, GLP-1, GIP, and blood glucose levels). To examine whether there is a correlation between the change in ACTH levels before and after GHRP-2 administration and each hormone related to glucose metabolism (GH, ACTH, cortisol, insulin, glucagon, GLP-1, GIP, and blood glucose levels). To examine whether there is a correlation between the change in cortisol levels before and after GHRP-2 administration and each hormone related to glucose metabolism (GH, ACTH, cortisol, insulin, glucagon, GLP-1, GIP, and blood glucose levels). To examine whether there is a correlation between the change in blood glucose levels before and after GHRP-2 administration and each hormone related to glucose metabolism (GH, ACTH, cortisol, insulin, glucagon, GLP-1, GIP, and blood glucose levels).	—

Measure

Time frame

The amount of change in GH levels before and after GHRP-2 administration and the amount of each hormone related to glucose metabolism (GH, ACTH, cortisol, insulin, glucagon, GLP-1, GIP, and blood glucose) will be compared for each disease. To verify whether there is a correlation between the change in GH levels before and after GHRP-2 administration and each hormone related to glucose metabolism (GH, ACTH, cortisol, insulin, glucagon, GLP-1, GIP, and blood glucose levels). To examine whether there is a correlation between the change in ACTH levels before and after GHRP-2 administration and each hormone related to glucose metabolism (GH, ACTH, cortisol, insulin, glucagon, GLP-1, GIP, and blood glucose levels). To examine whether there is a correlation between the change in cortisol levels before and after GHRP-2 administration and each hormone related to glucose metabolism (GH, ACTH, cortisol, insulin, glucagon, GLP-1, GIP, and blood glucose levels). To examine whether there is a correlation between the change in blood glucose levels before and after GHRP-2 administration and each hormone related to glucose metabolism (GH, ACTH, cortisol, insulin, glucagon, GLP-1, GIP, and blood glucose levels).

—

Contacts

Public ContactHaremaru Kubo

Kitasato University Hospital

kubo.haremaru@kitasato-u.ac.jp+81-42-778-8111

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026