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General anesthesia induction and intracranial pressure

Effects of general anesthesia induction on intracranial pressure: Comparison between propofol and remimazolam

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
JPRN
Registry ID
JPRN-jRCT1031230607
Enrollment
46
Registered
2024-01-30
Start date
2024-02-15
Completion date
Unknown
Last updated
2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Patients undergoing general anesthesia General Anesthesia

Interventions

The study is randomized between propofol and lemimazolam anesthesia.
D007427, D015742, C522201
Intracranial Pressure, Propofol, Remimazolam.

Sponsors

Ogawa Yojiro
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: 1. Healthy adult consented to participate in this study. 2. Patients with an American Society of Anesthesiologists pre-anesthesia risk rating of 2 or less 3. Patient who can be obtained cerebral blood flow velocity signal by transcranial Doppler ultrasonography.

Exclusion criteria

Exclusion criteria: 1. Patients who refuse to participate in the study. 2. Patients who are deemed inappropriate as research subjects by the principal investigator. 3. Patients with a history of allergy to general anesthetic or food (dairy and soybean). 4. Patients with an American Society of Anesthesiologists pre-anesthesia risk rating of 3 or more. 5. Patients who have cerebrovascular disorder and an abnormal value of the intracranial pressure. 6. Patients undergoing an epidural or a peripheral nerve block with general anesthesia.

Design outcomes

Primary

MeasureTime frame
Intracranial Pressure

Secondary

MeasureTime frame
Cerebral blood flow, vaital sign, autonomic nerve activity, circulatory regulation.

Contacts

Public ContactYojiro Ogawa

Nihon university school of medicione

ogawa.yojiro@nihon-u.ac.jp+81-3-3972-8111

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026