Stratification and standardization of corticosteroid treatment of acute exacerbations of interstitial pneumonia according to its severity.

Stratification and standardization of corticosteroid treatment of acute exacerbations of interstitial pneumonia according to its severity. - SCAEIPstudy

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-jRCT1031220450

Enrollment

Registered

2022-11-21

Start date

2022-11-21

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Acute exacerbation of interstitial pneumonia Idiopathic Interstitial Pneumonias, acute exacerbation of interstitial pneumonia, corticosteroids

Interventions

Patients will be classified into score 0, 1, 2, or 3 based on the total score using a previously published scoring system based on P/F ratio, CRP, and chest CT images at the onset of acute exacerbatio

12(1):1134). Steroids will be administered according to the following schedule according to the total score, and the total steroid dosage at 3, 6, and 12 months will be compared with that in previous

Stratification by severity score of acute exacerbation of interstitial pneumonia

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Patients diagnosed with acute exacerbation of interstitial pneumonia

Exclusion criteria

Exclusion criteria: Patients who cannot obtain written informed consent. Patients who cannot use corticosteroids.

Design outcomes

Primary

Measure	Time frame
Cumulative steroid dose at 3, 6, and 12 months	—

Secondary

Measure	Time frame
(1) Comparison of steroid complications at 3, 6, and 12 months with previous cases matched for age and severity of acute exacerbation. (ii) Prognosis at 3, 6, and 12 months, compared with previous cases matched for age and severity of acute exacerbations, and validation of the scoring system. (iii) Percentage of patients who required increased doses of steroids after treatment according to the protocol, compared to previous cases matched for age and severity of acute exacerbation. (iv) Bone density within 1 year after the onset of acute exacerbation will be measured and compared with bone density in the stable period. (v) Effectiveness and efficacy after steroid administration PaO2/FiO2 ratio and SpO2/FiO2 ratio at onset, and chest CT images at 1, 3, and 6 months after onset will be compared.	—

Measure

Time frame

(1) Comparison of steroid complications at 3, 6, and 12 months with previous cases matched for age and severity of acute exacerbation. (ii) Prognosis at 3, 6, and 12 months, compared with previous cases matched for age and severity of acute exacerbations, and validation of the scoring system. (iii) Percentage of patients who required increased doses of steroids after treatment according to the protocol, compared to previous cases matched for age and severity of acute exacerbation. (iv) Bone density within 1 year after the onset of acute exacerbation will be measured and compared with bone density in the stable period. (v) Effectiveness and efficacy after steroid administration PaO2/FiO2 ratio and SpO2/FiO2 ratio at onset, and chest CT images at 1, 3, and 6 months after onset will be compared.

—

Contacts

Public ContactSusumu Sakamoto

Toho universitiy omori medical center

susumu1029@med.toho-u.ac.jp+81-3-3762-4151

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026