Heart failure with preserved ejection fraction
Conditions
Interventions
Exercise stress echocardiography with simultaneous peripheral venous pressure measurement and expired gas analysis
Sponsors
Obokata Masaru
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1) Age equal to or more than 20 years old 2) Patients with EF of 50% or more than 50% 3) Patients with established HFpEF or subjects who are suspected of HFpEF 4) Patients with possible new initiation of medications such as empagliflozin, sacubitril valsartan, or spironolactone. 5) Patients who give written consent to participate in this study
Exclusion criteria
Exclusion criteria: 1) Patients with mimic HFpEF: Decompensated heart failure, history of EF less than 40%, pulmonary arterial hypertension, more than mild aortic or mitral valve stenosis, more than moderate aortic or mitral valve regurgitation, cardiomyopathy, acute coronary syndrome, complex adult congenital heart disease s 2) Subjects who cannot keep cycle ergometry exercise (0 watts) for more than 30 seconds 3) Patients who are judged to be unsuitable for the study by the investigators
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Change in estimated pulmonary artery systolic pressure during peak exercise 2-4 months after the intervention | — |
Secondary
| Measure | Time frame |
|---|---|
| 1) Changes in hemodynamics, cardiovascular reserve, and peak oxygen consumption 2-4 months after the intervention 2) Association between the intervention and outcome 3) Association between changes in hemodynamics, cardiovascular reserve, and peak oxygen consumption 2-4 months after the intervention and outcome *: outcome=a composite of all-cause death, heart failure events (hospitalization or unplanned visit requiring iv diuretics) | — |
Contacts
Public ContactTomonari Harada
Gunma University Hospital
Outcome results
None listed