Efficacy of intraoperative Nitrous Oxide use on postoperative pain in patients with cervical spinal cord injury

Efficacy of intraoperative Nitrous Oxide use on postoperative pain in patients with cervical spinal cord injury: a randomized controlled trial

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-jRCT1031210580

Enrollment

Registered

2022-01-25

Start date

2022-05-11

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Spinal cord injury Neuropathic pain,Spinal cord injury

Interventions

After the introduction of anesthesia, assigned to receive 60% nitrous oxide in 40% oxygen or Air-oxygen-sevoflurane during anaesthesia.

D009609

nitrous oxide

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Patients aged 20 years or older with ASIA classification C or D cervical spinal cord injury who underwent urgent spinal surgery

Exclusion criteria

Exclusion criteria: Pneumothorax , head injury, limb injury : fracture/nerve injury, non-speaking Japanese, impaired consciousness ,Complications of psychiatric disorders :such as suicidal ideation, complications of other trauma, history of blood disorders

Design outcomes

Primary

Measure	Time frame
Pain intensity:NRS for the past 24 hours before and after surgery	—

Secondary

Measure	Time frame
1.Changes in the range of postoperative neuropathic pain:The range of pain/numbness along the upper limbs dermatome 2. Properties and intensity of neuropathic pain in the past 24 hours :NPSI 3. Psychological state:HADS 4. ADL:EQ5D 5. Degree of improvement:PGIC 6. Relationship between time to surgery and pain 1,2 are assessed at 1D, 2W, 3M, 6M, and 4 to 6 at 2W, 3M, 6M.	—

Contacts

Public ContactMayu Sugimoto

Saitama Medical Center, Saitama Medical University

mayu_h@saitama-med.ac.jp+81-492283654

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026