Effect of zoledronic acid on osteoporosis for the chronic stroke patients

Effect of zoledronic acid on osteoporosis for the chronic stroke patients- prospective multicenter intervention study - Effect of zoledronic acid on osteoporosis for the chronic stroke patients

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

JPRN

Registry ID

JPRN-jRCT1031190091

Enrollment

Registered

2019-09-03

Start date

2019-09-03

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

stroke stroke

Interventions

Injection of Zoledronic Acid Hydrate 15mg once a year

D007267

Zoledronic Acid Hydrate

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1.Hemiparesis patients based on first onset stroke. 2.Age more than 60 years. 3.More than 90 days from onset of stroke. 4.Patients who could come to outpatients clinic following to the study protocol. 5.Witten informed consent.

Exclusion criteria

Exclusion criteria: 1)Patients receiving other therapies which affect bone metabolism (teriparatide, denosumab, bisphosphonate injection and zoledronic acid). 2)Allergy against zoledronic acid or other bisphosphonate. 3)Severe renal failure ( eGFR<35ml/min) 4)Hypocalcemia (albumin-adjusted Ca <8.5mg/dl) 5)Severe complications 6)History of operation for lumber spine or femur fracture. 7)Severe denegerative spondylosis or severe hip arthrosis 8)Currently receiving invasive dental treatment such as tooth extraction, or shortly after tooth extraction 9) History of osteonecrosis of jaw

Design outcomes

Primary

Measure	Time frame
Bone Mineral Density of lumbar spine and bilateral femur necks	—

Secondary

Measure	Time frame
Bone metabolism marker, Physical function test, Fragility fracture	—

Contacts

Public ContactToshiyuki Fujiwara

Juntendo University Hospital

t-fujiwara@juntendo.ac.jp+81-3-3813-3111

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026