Prevention of acute kidney injury by cardiopulmonary bypass: role of haptoglobin administration for hemolysis

Haptoglobin Prevention of Hemolytic Acute Kidney Injury in Cardiac Surgery - HARMONICA

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-jRCT1031190038

Enrollment

336

Registered

2019-06-11

Start date

2019-06-11

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Valvular heart disease Hemolysis, cardiopulmonary bypass, operation

Interventions

In patients who require a heart-lung machine for 2 or more hours, administer human haptoglobin based on plasma free hemoglobin concentration to prevent kidney damage, and examine whether the in dex of

D006242

Haptoglobin

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1) Patients aged >=20 years 2) Patients undergoing heart surgeries under artificial heart-lung machine for a long period of time at Tokyo Women's Medical University Hospital (Definition of long period of time: 2 hours or more) 3) Patients who have written consent to participate in this study

Exclusion criteria

Exclusion criteria: 1) Dialysis patients, after kidney transplantation, on e kidney 2) Congenital kidney disease 3) Emergency surgery

Design outcomes

Primary

Measure	Time frame
The occurrence of acute kidney failure	—

Secondary

Measure	Time frame
Hemodialysis Stage 1-3 in the AKI diagnostic criteria according to the KDIGO guidelines Time from entering the ICU to extubation, and ICU stay time Death during hospitalization or 30 days after surgery MAKE 1, 3 and 5 years	—

Contacts

Public ContactYasuko Nagasaka

Tokyo Women's Medical University Hospital

yasukonagasaka@gmail.com+81-3-3353-8111

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026