Strategy of discontinuation of PPI

How to attempt discontinuation for long-term use of PPI

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-jRCT1031180383

Enrollment

Registered

2019-03-20

Start date

2019-08-21

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Gastroesophageal reflux disease GERD

Interventions

Abrupt withdrawal of PPI, and Step-down withdrawal of PPI

withdrawal

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: GERD patients with long-time use PPI and without symptoms

Exclusion criteria

Exclusion criteria: NSAIDs user, H.pylori positive, and/or severe esophagitis patients

Design outcomes

Primary

Measure	Time frame
Withdrawal rate of PPI after 24 weeks	—

Secondary

Measure	Time frame
Withdrawal rate of PPI after 48 weeks	—

Contacts

Public ContactMariko Hojo

Juntendo University Hospital

mhojo@juntendo.ac.jp+81-3-3813-3111

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026