A study of remote ischemic preconditioning during surgery to improve recovery after posterior cervical decompression for cervical spondylotic myelopathy

Remote Ischemic Preconditioning to Improve Postoperative Recovery After Posterior Cervical Decompression for Cervical Spondylotic Myelopathy: A Multicenter, Randomized, Double-Blind, Sham-Controlled Trial - RIPCORD-CSM trial

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-jRCT1030260077

Enrollment

100

Registered

2026-04-22

Start date

2026-04-22

Completion date

Unknown

Last updated

2026-09-14

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Cervical spondylotic myelopathy cervical spondylotic myelopathy, cervical myelopathy, degenerative cervical disease

Interventions

RIPC using a lower-limb tourniquet after induction of general anesthesia. In the RIPC group, the cuff is inflated to systolic blood pressure +130 mmHg for 5 minutes followed by 5 minutes of deflation

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1) Age 18 years or older at the time of informed consent 2) Diagnosed with cervical spondylotic myelopathy based on clinical and imaging findings 3) Scheduled to undergo posterior cervical decompression surgery 4) Written informed consent obtained from the participant

Exclusion criteria

Exclusion criteria: 1) Previous surgery at the same level, combined anterior surgery, or concomitant spinal surgery at another site 2) Emergency surgery or insufficient time to perform the RIPC procedure 3) Contraindications to RIPC, including severe soft tissue injury, fracture or vascular injury, or peripheral vascular disease 4) Severe cardiopulmonary, hepatic, or renal dysfunction, severe coagulopathy, pregnancy, or breastfeeding 5) Expected poor follow-up adherence or poor treatment compliance 6) Considered inappropriate for study participation by the principal investigator

Design outcomes

Primary

Measure	Time frame
JOA recovery rate at 3, 6, and 12 months after surgery JOA recovery rate (%) = (postoperative JOA score - preoperative JOA score) / (17 - preoperative JOA score) x 100	—

Secondary

Measure	Time frame
1) Incidence of postoperative C5 palsy (a decrease of >=2 grades in manual muscle testing of C5-innervated muscles [deltoid and biceps] compared with preoperative status) 2) JOACMEQ at 3, 6, 12, and 24 months after surgery 3) EQ-5D at 3, 6, 12, and 24 months after surgery 4) Intraoperative and postoperative complications (including infection, reoperation, and deep vein thrombosis) 5) RIPC-related local adverse events (including skin injury and pain)	—

Measure

Time frame

1) Incidence of postoperative C5 palsy (a decrease of >=2 grades in manual muscle testing of C5-innervated muscles [deltoid and biceps] compared with preoperative status) 2) JOACMEQ at 3, 6, 12, and 24 months after surgery 3) EQ-5D at 3, 6, 12, and 24 months after surgery 4) Intraoperative and postoperative complications (including infection, reoperation, and deep vein thrombosis) 5) RIPC-related local adverse events (including skin injury and pain)

—

Contacts

Public ContactTetsuhiko Mimura

Shinshu University Hospital

tettim3@yahoo.co.jp+81-263372659

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Sep 19, 2026