Investigation of a sensory masking method to improve the palatability of rebamipide mouthwash in patients with head and neck cancer

Status

Recruiting

Phases

Early Phase 1

Study type

Interventional

Source

JPRN

Registry ID

JPRN-jRCT1030250292

Enrollment

Registered

2025-08-14

Start date

2025-08-21

Completion date

Unknown

Last updated

2026-09-14

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Pharyngeal Neoplasms cancer

Interventions

Randomized allocation of sensory masking flavor agents added to rebamipide mouthwash.

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Patients with head and neck cancer who visited the Department of Otolaryngology, University of Yamanashi Hospital, between the date of approval by the head of the research institution and September 30, 2028, Patients who provided written informed consent to participate in this study by signing the consent form themselves.

Exclusion criteria

Exclusion criteria: Pregnant or lactating women. Patients who already have oral mucositis that affects their ability to eat. Patients with a history of allergy to rebamipide or the sensory masking agents. Patients unable to communicate due to cognitive impairment or other reasons. Any other individuals deemed inappropriate for inclusion by the principal investigator or co-investigators.

Design outcomes

Primary

Measure	Time frame
Overall taste evaluation (VAS)	—

Secondary

Measure	Time frame
Bitterness (VAS),Sweetness (VAS),Sourness (VAS), Astringency (VAS),Overall palatability (5-point scale),Acceptability of the formulation (5-point scale)	—

Contacts

Public ContactAkihiro Nagai

Department of Pharmacy, University of Yamanashi Hospital, Yamanashi, Japan

nagaia@yamanashi.ac.jp+81-54-273-1111

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Sep 19, 2026