Omphalocele, CDH, Extremely premature baby
Conditions
Interventions
None listed
Sponsors
Kosaka Seitaro
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: From the date of research approval until March 31, 2028, this study will include patients with conditions that are prone to cause neonatal pulmonary hypertension specifically, congenital diaphragmatic hernia, omphalocele, and extremely low birth weight infants who are born at the Department of Pediatric Surgery and Pediatric Urology at Juntendo University Hospital, as well as at the Departments of Pediatric Surgery at Juntendo University Urayasu Hospital and Juntendo University Nerima Hospital. In addition, umbilical cords will be collected from term-born infants to serve as a comparison group.
Exclusion criteria
Exclusion criteria: Individuals whom the principal investigator deems unsuitable as research subjects will be excluded. Those who do not meet any of the exclusion criteria will be considered eligible.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| genes of HUVEC of all targeted diseases | — |
Secondary
| Measure | Time frame |
|---|---|
| Test results (blood tests, ultrasound), Pre- and postoperative course (severity of pulmonary hypertension) (right ventricular systolic time, pulmonary artery acceleration time, right ventricular wall thickening, right ventricular dilation, degree of tricuspid/pulmonary regurgitation), Number of days requiring vasopressor administration, inhaled nitric oxide, and mechanical ventilation | — |
Contacts
Public ContactSeitaro Kosaka
Juntendo University hospital
Outcome results
None listed