mild neurocognitive disorder,amnestic disorder,dementia, etc.
Conditions
Interventions
None listed
Sponsors
Abe Hiroki
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Neurocognitive impairment group (dementia patients) Patients who meet all of the following criteria are eligible 1)Patients who meet the diagnostic criteria for mild neurocognitive disorder, amnesia, or dementia as defined by ICD-11. 2)Patients who are 18 years of age or older at the time of informd consent 3)Patients whose consent can be obtained in writing from the individual (written consent by a substitute is also acceptable when written consent is not possible due to cognitive impairment). (In this case, a surrogate is defined as an adult and the patient's spouse, parents, siblings, children, relatives living in the same household, a person equivalent to a close relative, or a caregiver who can understand the patient's living environment and needs on a daily basis, in other words, a person who partially shares the social and psychological circumstances of the patient and can represent the patient's wishes and interests.) 4)Gender is not required
Exclusion criteria
Exclusion criteria: Neurocognitive impairment group, Sleep/wakefulness disorder group, Healthy control group Persons who have any of the following will not be included in this study 1)Those with pacemakers or metal objects in the body that are not compatible with 3T MRI 2)Patients with tattoos or art makeup 3)Patients with a strong fear of claustrophobia 4)Those who are pregnant or may be pregnant, and those who are breast-feeding. 5)Others who are deemed inappropriate as research subjects by the physician who is the researcher.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Changes over time in AMPA receptor expression density from PET images. | — |
Secondary
| Measure | Time frame |
|---|---|
| Changes over time in tau and Abeta distribution density from PET images. | — |
Contacts
Public ContactHiroki Abe
Yokohama City University Hospital
Outcome results
None listed