Examining the Effects of Isometric Exercise on Arterial Health and Muscle Function in Heart Patients" (HEART-EX)

The Impact of Isometric Contraction Exercise on Arterial Elasticity and Skeletal Muscle Metabolism in Patients with Cardiac Disease - The Impact of Isometric Contraction Exercise on Arterial Elasticity and Skeletal Muscle Metabolism in Patients with Cardiac Disease: A Comprehensive Study" (ICE-ACE)

Status

Recruiting

Phases

Phase 1

Study type

Interventional

Source

JPRN

Registry ID

JPRN-jRCT1030250008

Enrollment

200

Registered

2025-04-28

Start date

2023-07-04

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Heart failure, Acute myocardial infarction Heart failure(HF), Congestive heart failure (CHF) , Chronic heart failure, Left-sided heart failure, Cardiac dysfunction, Acute myocardial infarction (AMI)

Interventions

Isometric contraction exercises targeting the quadriceps will be implemented as part of the resistance training program.

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Patients hospitalized for cardiovascular diseases, including heart failure and acute myocardial infarction, who received cardiac rehabilitation during hospitalization

Exclusion criteria

Exclusion criteria: Patients with impaired cognitive function who are unable to comprehend the purpose of the study, those with gait disturbance, and those with severe heart failure including end-stage heart failure will be excluded from the study.

Design outcomes

Primary

Measure	Time frame
Arterial stiffness, Skeletal muscle metabolism, physical function	—

Contacts

Public ContactOgawa Akihiro

Toho university sakura medical center

rtp-ogw0318@sakura.med.toho-u.ac.jp+81-434628811

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026