Trends in oxidative and antioxidant indices in cardiopulmonary bypass. A prospective observational study

Status

Active, not recruiting

Phases

Phase 1

Study type

Observational

Source

JPRN

Registry ID

JPRN-jRCT1030230696

Enrollment

Registered

2024-03-13

Start date

2022-01-17

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Subject to cardiac surgery

Interventions

None listed

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: A case of extracorporeal circulation using an artificial heart-lung machine in cardiac surgery under general anesthesia

Exclusion criteria

Exclusion criteria: Patients who fall under G3a (45 ml/min/1.73 m2) or lower from GFR category (ml/min/1.73 m2) in the CKD Clinical Practice Guidelines 2018 12) issued by the Japanese Society of Nephrology. Patients who undergo other surgical procedures or complex surgeries Patients undergoing emergency surgery When the subject or the subject's family refuses or withdraws consent. Other cases in which the principal investigator determines that the patient is inappropriate.

Design outcomes

Primary

Measure	Time frame
Comparison of transition values of oxidative stress and antioxidant capacity in cases of extracorporeal circulation using artificial heart lung in cardiac surgery	—

Secondary

Measure	Time frame
Analysis of differences in oxidative stress and antioxidant capacity values by site of blood collection Correlations with blood gas, biochemistry, and blood counts Relationship to extracorporeal circulatory control values Relationship to inflammatory cytokines	—

Contacts

Public ContactTsubasa Yamashiro

International University of Health and Welfare

yamashiro283@iuhw.ac.jp+81-476-20-7701

Outcome results