central nervous system lymphoma
Conditions
Interventions
In HD-MTX therapy, the standard care for oral mucositis is brushing with a toothbrush and gargling with allopurinol gargling water. Therefore, we will compare two groups: a group gargles with allopuri
Sponsors
TADERA Noriyuki
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Persons aged 20 years or older who can write informed consent before starting treatment 2. Those receiving first-time HD-MTX therapy 3. Persons who are orally ingesting regular food (not soft vegetarian food, swallowing food, etc.) 4. Those with good oral conditions 5. Persons who are able to perform oral care on their own
Exclusion criteria
Exclusion criteria: 1. Those with a history of long-term use of steroids, immunodeficiency, or diabetes 2. Those suffering from an infectious disease 3. Persons who are currently being treated for cancer in another location (if they have received treatment for cancer in another location in the past, those who have completed surgery, drug therapy, or radiation therapy for less than 2 years) 4. Persons who are allergic to sesame oil
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The severity of oral mucositis using CTCAE v5.0 | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Inflammatory changes by oral mucosal cytology 2. Dry mouth, dysphagia, pain, taste changes, anorexia, and nausea using PRO-CTCAE as subjective evaluations by research subjects | — |
Contacts
Public ContactKenji KATSURAGI
Kitasato University
Outcome results
None listed