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Generation and phenotypic evaluation of chronotyped iPS cell-derived human SCN organoids

Generation and phenotypic evaluation of chronotyped iPS cell-derived human SCN organoids

Status
Active, not recruiting
Phases
Early Phase 1
Study type
Observational
Source
JPRN
Registry ID
JPRN-jRCT1030230322
Enrollment
8
Registered
2023-09-04
Start date
2023-09-04
Completion date
Unknown
Last updated
2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Healthy subjects

Interventions

None listed

Sponsors

Kitamura Shingo
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: 1) Persons who are between 20 and 35 years of age at the time of obtaining consent.

Exclusion criteria

Exclusion criteria: 1) Those with difficulty in blood collection due to alcohol allergy or vasovagal reflex, etc. 2) Patients with pre-existing medical conditions (cardiovascular, liver, endocrine, brain/neurological, psychiatric, etc.), taking therapeutic drugs, or having a history of such conditions that may affect the results of the study 3) Persons who are dependent on alcohol or who are found to be in the habit of excessive alcohol consumption 4) Those who have a habit of taking drugs or supplements that affect sleep 5) Those who have engaged in time-lagged travel or shift work at least six months prior to the experiment. 6) Any other person who is deemed inappropriate by the principal investigator.

Design outcomes

Primary

MeasureTime frame
(1) To examine whether the circadian rhythmicity and cycle length observed in the luminescence peak of clock gene expression of SCN organoids reflect individual chronotypic characteristics. (2) To examine whether the circadian rhythmicity and cycle length observed in the luminescence peak of clock gene expression of SCN organoids reflect individual sleep habits.

Contacts

Public ContactTaisuke Eto

National Center of Neurology and Psychiatry

eto@ncnp.go.jp+81-42-346-2071

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026