Association between oral hypofunction and heart disease

Clinical significance of oral hypofunction on physical performance and clinical outcomes in late-middle age elder patients with heart disease

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

JPRN

Registry ID

JPRN-jRCT1030230205

Enrollment

300

Registered

2023-07-05

Start date

2023-05-15

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

heart disease

Interventions

None listed

Eligibility

Inclusion criteria

Inclusion criteria: Hospitalized patients due to heart disease who are 50 years of age or older, and are underwent cardiac rehabilitation All patients provided written informed consent.

Exclusion criteria

Exclusion criteria: Patients unable to answer the questionnaire due to severe cognitive dysfunction Patients who cannot have a dental examination because of difficulty sitting or limited mouth opening. Investigator made the patient unsuitable for inclusion.

Design outcomes

Primary

Measure	Time frame
Investigation of oral hypofunction and physical performance, and effects of oral hypofunction on clinical outcomes of heart diseases	—

Secondary

Measure	Time frame
Association between each component of oral hypofunction and cardiopulmonary capacity (cardiopulmonary exercise test or 6-min walking distance) Comparison of blood biomarkers between presence and absence of oral hypofunction Association between each component of oral hypofunction and physical performance such as short physical performance battery, skeletal muscle mass, knee extension strength, or grip strength Association between each component of oral hypofunction and advanced glycation end products Association between each component of oral hypofunction and dietary style or malnutrition Association between each component of oral hypofunction and cognitive function Association between each component of oral hypofunction and QOL evaluated by SF-12	—

Measure

Time frame

Association between each component of oral hypofunction and cardiopulmonary capacity (cardiopulmonary exercise test or 6-min walking distance) Comparison of blood biomarkers between presence and absence of oral hypofunction Association between each component of oral hypofunction and physical performance such as short physical performance battery, skeletal muscle mass, knee extension strength, or grip strength Association between each component of oral hypofunction and advanced glycation end products Association between each component of oral hypofunction and dietary style or malnutrition Association between each component of oral hypofunction and cognitive function Association between each component of oral hypofunction and QOL evaluated by SF-12

—

Contacts

Public ContactShinji Koba

Showa University

skoba@med.showa-u.ac.jp+81-3-3784-8539

Outcome results