Evaluation of microvasculr dysfunction in CTEPH

Evaluation of microvasculr dysfunction in chronic thromboembolic pulmonary hypertension

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-jRCT1030220553

Enrollment

Registered

2022-12-29

Start date

2022-12-29

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

chronic thromboembolic pulmonary hypertension (CTEPH), chronic thromboembolic desease (CTED)

Interventions

A pressure wire is used to measure the pulmonary microcirculatory indices based on the principle of thermodilution method. In addition to the ordinal therapeutic manipulation, 3 ml of saline injection

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Patients with chronic thromboembolic pulmonary hypertension (CTEPH) or chronic thromboembolic desease (CTED) who underwent balloon pulmonary angioplasty (BPA) in our institution.

Exclusion criteria

Exclusion criteria: None

Design outcomes

Primary

Measure	Time frame
A pressure wire allows the measurement of mean transit time (Tmn) using the principle of thermodilution method. In addition, nitric oxide (NO) inhalation is used to induce hyperemia and assess pulmonary microvascular dilatation. Local pulmonary artery pressure and Tmn are used to calculate and assess the following pulmonary microcirculatory indices. Vascular flow reserve (VFR) = Resting Tmn/Hyperemic Tmn Index of microcirculatory resistance (IMR) = Distal pulmonary artery pressure/1/Resting Tmn Resistive reserve ratio (RRR) = Resting IMR/Hyperemic IMR	—

Measure

Time frame

A pressure wire allows the measurement of mean transit time (Tmn) using the principle of thermodilution method. In addition, nitric oxide (NO) inhalation is used to induce hyperemia and assess pulmonary microvascular dilatation. Local pulmonary artery pressure and Tmn are used to calculate and assess the following pulmonary microcirculatory indices. Vascular flow reserve (VFR) = Resting Tmn/Hyperemic Tmn Index of microcirculatory resistance (IMR) = Distal pulmonary artery pressure/1/Resting Tmn Resistive reserve ratio (RRR) = Resting IMR/Hyperemic IMR

—

Contacts

Public ContactSato Shuji

Toho University Sakura Medical Center

shuuji.satou@med.toho-u.ac.jp+81-43-462-8811

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026