Patients (and their donors) who have undergone living-donor liver transplantation and are scheduled
Conditions
Interventions
None listed
Sponsors
Uchida Koichiro
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: [Recipient selection criteria] 1) Among patients who have undergone living-donor liver transplantation, those who are scheduled to undergo liver biopsy 2) A person who has voluntarily obtained written consent from the person or his / her substitute for participation in this research. [Donor selection criteria] 1) Recipients whose organs have been donated by themselves have given written consent to participate in this study. 2) Who have obtained free and voluntary written consent for participation in this study from the recipient.
Exclusion criteria
Exclusion criteria: 1) Patients who are considered difficult to carry out this study by the principal inverstigator,ect.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1.Liver histopathological findings 2.Expression of tolerant/inflammatory cells in peripheral blood 3.Expression distribution and intensity of tolerant/inflammatory cells in the graft 4.Expression level of inflammatory/inhibitory molecule/cytokine genes in the graft 5.Expression level of inflammatory/inhibitory molecule/cytokine genes in lymphocytes infitrating into the graft 6.Evaluation of immune anti-donor responsiveness(CD4+T cell,CD8+T cell division ability) | — |
Contacts
Public ContactSaori Hirota
Juntendo University
Outcome results
None listed