How do the exosomes derived from the pancreatic cnacer cell promote the drug resisitance ?

Clarification of how the exosomes derived from the pancreatic cnacer cell promote the drug resisitance through the communication with the cancer associated fibroblast .

Status

Recruiting

Phases

Early Phase 1

Study type

Observational

Source

JPRN

Registry ID

JPRN-jRCT1030220485

Enrollment

Registered

2022-12-02

Start date

2022-11-08

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

problem studied pancreatic neoplasm, exosome

Interventions

None listed

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Patients with pancrearic cancer who will undergo a surgical procedure at the Jikei University School of Medicine.

Exclusion criteria

Exclusion criteria: There is no exlsion criteria other than the age.

Design outcomes

Primary

Measure	Time frame
Half maximal Inhibitory Concentration(IC50%) of pancreatic caner cell growth when cell lines are treated with secretor factors from cancer associated fibroblast (CAF) stimulated by exosomes from pancreatic cancer cell lines of wild type, knockdown or overexpression of CD44v6.	—

Secondary

Measure	Time frame
(1) miRNA of pancreatic cancer cells treated with secretor factors from CAF. (2) miRNA and the expression of proteins of CAF stimulated by exosomes from pancreatic cancer cell lines of wild type, knockdown or overexpression of CD44v6. (3) The ammount of serum CD44v6 exosomes before operation,after operation and at the recurrence.	—

Contacts

Public ContactShimamoto Nana

The Jikei University School of Medicine

nanahachinetyou@gmail.com+81-70-3914-1093

Outcome results