A depressive episode in unipolar depressive disorder or bipolar disorder unipolar depression, bipolar disorder, depressive episode
Conditions
Interventions
Sleep deprivation therapy (wake therapy). During the intervention period, study subjects undergo three cycles of sleep manipulation, each cycle consisting of total sleep deprivation followed by recove
D012892
sleep deprivation therapy, wake therapy
Sponsors
Yoshiike Takuya
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1) Aged 20 years or older 2) Capable to provide informed consent 3) Presenting a depressive episode in the course of depressive disorder or bipolar disorder (DSM-5 criteria) 4) Admitted to our hospital 5) A baseline Hamilton Rating Scale for Depression (17-item) score of 14 or higher
Exclusion criteria
Exclusion criteria: 1) Presenting psychotic features in the depressive episode 2) A score greater than 2 on the suicide item of the Hamilton Rating Score for Depression 3) A score greater than 2 on the agitation item of the Hamilton Rating Score for Depression 4) Severe personality disorder(s) 5) A history of drug or alcohol dependency or abuse within the last six months 6) A history of epilepsy 7) Receiving electroconvulsive therapy, repetitive transcranial magnetic stimulation, or cognitive-behavioral therapy 8) Pregnancy 9) Major medical and neurological disorders
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Change in the score of the Hamilton Rating Scale for Depression | — |
Secondary
| Measure | Time frame |
|---|---|
| Change in the score or value of the following measures: Quick Inventory of Depressive Symptomatology, Young Mania Rating Scale, Visual Analogue Scale (mood, sleepiness), Clinical Global Impression, time perception, Insomnia Severity Index, Epworth Sleepiness Scale, Magnetic Resonance Imaging variables, electroencephalographic variables, actigraphic variables, general cognition (THINC-it), peripheral blood inflammatory variables, clock gene polymorphism | — |
Contacts
Public ContactTakuya Yoshiike
National Center of Neurology and Psychiatry
Outcome results
None listed