Depression,Bipolar disorder,Autism spectrum disorder,Schizophrenia
Conditions
Interventions
None listed
Sponsors
Miyazaki Tomoyuki
Takahashi Takuya
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: The data must be from a pilot study (UMIN000025132) to compare the efficacy of the radioligand [11C]K-2 in the development of cross-disease diagnostics in depression, bipolar disorder, schizophrenia, addiction, ASD, epilepsy, FTD cases and healthy controls, and [11C]K-2 imaging data and MRI imaging data stored in the Department of Physiology, Yokohama City University, which can be analyzed in patients with depression, bipolar disorder, schizophrenia and ASD and in healthy controls. The data were obtained in the 'A clinical trial to examine age-and-sex-related changes of AMPA receptor density in healthy volunteers.' and the data should be analyzable in males in their 20s-40s. The data should be from [11C]K-2 images and MRI images taken in a cross-sectional PET study using [11C]K-2 (jRCTs031190197) and stored in the Department of Physiology, Yokohama City University, and should be available for analysis. The data must be from [11C]K-2 imaging data and MRI imaging data taken in a cross-sectional PET study using [11C]K-2 (jRCTs031190150) and stored in the Department of Physiology, Yokohama City University, and must be available for analysis. The data must be from [11C]K-2 imaging data and MRI imaging data taken in a cross-sectional PET study using [11C]K-2 (jRCTs031190149) and stored in the Department of Physiology, Yokohama City University, and must be available for analysis.
Exclusion criteria
Exclusion criteria: none
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Product rate correlation coefficients and significance probabilities of SUVR and BPnd's Spearman's correlation coefficients for the 10 regions calculated from healthy subjects and each psychiatric disorder case. | — |
Secondary
| Measure | Time frame |
|---|---|
| Correlation between SUVR and each clinical assessment score in patients with psychiatric disorders Comparison of SUVR in healthy and mentally ill patients Comparison of cortical volume, brain substance concentrations, FC and FA values in healthy subjects and psychiatric patients Correlation between cortical volume, brain substance concentrations, FC and FA values and each clinical assessment score in patients with psychiatric disorders | — |
Contacts
Public ContactTsuyoshi Eiro
Yokohama City University School of Medicine
Outcome results
None listed