A clinical trial to clarify the mechanism of epilepsy as seen through AMPA receptors.

Mechanisms of Focal and Generalized Epilepsy Focusing on AMPA Receptor Functional Alterations

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

JPRN

Registry ID

JPRN-jRCT1030220299

Enrollment

Registered

2022-08-27

Start date

2022-08-15

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Epilepsy epilepsy, seizure, eeg,cognition

Interventions

None listed

Eligibility

Sex/Gender

Male

Inclusion criteria

Inclusion criteria: The data were obtained in the 'A clinical trial to examine age-and-sex-related changes of AMPA receptor density in healthy volunteers.' and the data should be analyzable in males in their 20s-40s. The data must be from a pilot study (UMIN000025132) 'The clinical trial to examine the densities of AMPA receptors in epilepsy patients with [11C]K-2'The data must be [11C]K-2 imaging data and electroencephalogram (EEG) data that can be analyzed and that were taken within 1 year after the last seizure in epilepsy patients. The data must be an analyzable [11C]K-2 imaging data, IQ score, and EEG data of epilepsy patients taken in an epidemiological clinical study (UMIN000031624)'The clinical trial to examine the densities of AMPA receptors in epilepsy patients with [11C]K-2'

Exclusion criteria

Exclusion criteria: Nothing

Design outcomes

Primary

Measure	Time frame
Correlation between SUVR and amplitude in the gamma/theta band in patients with focal and generalized epilepsy	—

Secondary

Measure	Time frame
Correlation between SUVR and BPnd in Patients with Focal and Generalized Epilepsy Significant differences in SUVR between normal subjects and patients with focal or generalized epilepsy Correlation between SUVR and I Q score in patients with focal and generalized epilepsy	—

Contacts

Public ContactTsuyoshi Eiro

Yokohama City University School of Medicine

t196014a@yokohama-cu.ac.jp+81-45-787-2579

Outcome results