Eating disorders presenting as emaciation Anorexia Nervosa, Avoidant/Restrictive Food Intake Disorder
Conditions
Interventions
In CRT, eight sessions are conducted through tasks that are set specifically to improve cognitive function and that are interesting to the patient, and "look back and home work" is conducted so that t
Sponsors
Shimizu Eiji
Numata Noriko
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: (1) Patients who meet the diagnostic criteria for anorexia nervosa (including eating disorders that cause emaciation such as avoidance and restrictive food intake) in DSM-5. 2. BMI between 14.0 and 18.5 kg/m2 at the time of consent. 3. between 10 and 25 years of age at the time of consent. 4. onset of illness less than 3.5 years (5) Patients who have no coexisting serious psychiatric disorders according to the Brief Structured Interview for Mental Illness (M.I.N.I.). (6) Patients who have received a written consent form of their own free will and that of their parents or guardians after receiving sufficient explanation and understanding of the study. 7. be mentally and physically able to attend eight consecutive CRT sessions on a fixed day and time once a week.
Exclusion criteria
Exclusion criteria: 1. patients with serious physical complications 2. patients who require behavioral restrictions due to low body weight 3. patients with impending thoughts of death 4. patients who have difficulty in understanding assessment and treatment due to intellectual disability 5.Patients who have difficulty in understanding assessment and treatment due to poor understanding of Japanese, even considering their age. 6.Patients who have repeated antisocial behavior or have difficulty communicating with the researcher. 7.Patients who are judged by the investigator or sub-investigator to be inappropriate for the safe conduct of the study. (Patients on stable volume drug therapy will not be excluded.)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Change in the total number of errors at week 0 from the total number of errors at week 8 of the Wisconsin Card Sorting Test (WCST). | — |
Secondary
| Measure | Time frame |
|---|---|
| 1.Change from baseline in ROCFT total score and sub-item (order and style) score at 8 weeks. 2.Change from baseline in the number of Brixton errors at 8 weeks. 3. change from Week 0 (baseline) in WCST subscore other than total errors at 8 weeks 4. change from baseline in Eating Attitudes Test (EAT-26) score at 8 weeks 5. change from baseline in depression score using the Hospital Anxiety and Depression Scale (HADS) at 8 weeks 6. change from week 0 (baseline) in quality of life score at 8 weeks using the Pediatric Quality of Life Inventory (PedsQL) 7. change from week 0 (baseline) in scores on the EQ-5D-5L (Euro-QOL5Dimension) medicoeconomic health-related quality of life assessment scale at 16 weeks 8. Wechsler Adult Intelligence Scale-Forth Edition (WAIS-IV Intelligence Test) 9. Autism Spectrum Quotient (AQ) Safety secondary endpoints BMI at the time of assessment and at week 8, and no significant difference in the amount of change in BMI at week 8 from the time of assessment (baseline). 2) Frequency of adverse events Adverse events will be evaluated in three levels of severity: "mild, moderate, and severe" The correlation between the comorbidity of autism spectrum disorder and the treatment effect will be examined. 1. Autism Diagnosis Observation Schedule Second Edition (ADOS-2, semi-structured interview for the assessment of autism spectrum disorder) 2.Questionnaire to be completed by parents 1) Social Responsiveness Scale Second Edition (SRS-2, Interpersonal Responsiveness Scale) 2) Assessment of quality of life (QOL) using the Pediatric Quality of Life Inventory (PedsQL). 3)Child Autism Spectrum Quotient (Child AQ) 4) Attention Deficit Hyperactivity Disorder-Rating Scale (ADHD-RS, Attention Deficit/Hyperactivity Disorder: Rating Scale for Diagnosis, Screening, and Severity Assessment) | — |
Contacts
Public ContactNoriko Numata
Chiba University
Outcome results
None listed