Examination of safety and efficacy of pulmonary rehabilitation for patients with pulmonary hypertension: Appropriate exercise prescription on pulmonary hypertension during exercise

Status

Recruiting

Phases

Phase 2

Study type

Interventional

Source

JPRN

Registry ID

JPRN-jRCT1030210240

Enrollment

Registered

2021-08-13

Start date

2021-08-13

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

pulmonary hypertension pulmonary hypertension

Interventions

For patients with PH, we start pulmonary rehabilitation, including muscle strengthening exercises, endurance traning, respiratory muscle training (POWER Breathe MEDIC, Entry Japan Inc.), respiratory g

pulmonary rehabilitation

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1) Patients diagnosed with pulmonary hypertension (resting mPAP of 20 mmHg or more by right heart catheterization) 2) Patients who have already been treated with vasodilators for pulmonary hypertension and have not changed their treatment for more than 3 months 3) Patients with resting mPAP < 35 mmHg and PVR not increased by more than 15% compared with the previous right heart catheterization. 4) Patients who underwent a cardiopulmonary exercise stress test during the previous right heart catheterization 5) Patients aged 20 years or older at the time of consent. 6) Patients who have received sufficient explanation for participation in the study and have given written consent of their own free will with sufficient understanding.

Exclusion criteria

Exclusion criteria: 1) Patients with poorly controlled heart failure, heart disease, or arrhythmia 2) Patients with osteoarticular diseases or neuromuscular diseases that affect ADL 3) Patients with mental illness or cognitive decline that makes it difficult to perform the test safely and accurately

Design outcomes

Primary

Measure	Time frame
- Six-minute walking distance	—

Secondary

Measure	Time frame
- Health-related quality of life (emPHasis-10) - Physical activity (steps/day, activity time over 2.4 METs) - Quadriceps muscle strength - Respiratory muscle strength (PImax) - Pulmonary hemodynamics during exercise (PVR, mPAP / CO slope) - Cardiopulmonary exercise stress test (Peak VO2, VE vs. VCO2 slope, VD/VT)*. - Number of pulmonary rehabilitation (hospital visit, home) - Adverse events of pulmonary rehabilitaion - Resting pulmonary hemodynamics (RHC [mPAP, PVR, CO], echocardiography [TRPG, esPAP])	—

Measure

Time frame

- Health-related quality of life (emPHasis-10) - Physical activity (steps/day, activity time over 2.4 METs) - Quadriceps muscle strength - Respiratory muscle strength (PImax) - Pulmonary hemodynamics during exercise (PVR, mPAP / CO slope) - Cardiopulmonary exercise stress test (Peak VO2, VE vs. VCO2 slope, VD/VT)*. - Number of pulmonary rehabilitation (hospital visit, home) - Adverse events of pulmonary rehabilitaion - Resting pulmonary hemodynamics (RHC [mPAP, PVR, CO], echocardiography [TRPG, esPAP])

—

Contacts

Public ContactTakeshi Inagaki

Chiba University Hospital

inagaki-tb@hospital.chiba-u.jp+81-43-222-7171

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026