Aortic stenosis
Conditions
Interventions
In the control group, extubation will be performed after patient awakening at the predetermined target timing.
In the TIARA method, maintenance anesthesia will be switched to remimazolam in the latter
Sponsors
Yaksuhiji Tatsumi
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Patients scheduled to undergo transfemoral transcatheter aortic valve implantation (TF-TAVI) under general anesthesia who meet all of the following criteria: 1)Patients scheduled to undergo airway management with oral tracheal intubation 2)Patients scheduled for extubation in the operating room 3)Patients who have received sufficient explanation regarding this study and from whom written informed consent has been obtained, either from the patient or a legally authorized representative
Exclusion criteria
Exclusion criteria: 1)Patients in whom difficult mask ventilation, difficult intubation, or difficult extubation is anticipated 2)Patients at risk of vomiting or aspiration (e.g., esophageal achalasia) 3)Patients with a history of severe allergy to benzodiazepines, flumazenil citrate, remifentanil hydrochloride, naloxone hydrochloride, rocuronium bromide, or sugammadex sodium 4)Patients with a history of tolerance to benzodiazepines 5)Patients with a history of epilepsy 6)Patients deemed inappropriate for participation in this study by the principal investigator or sub-investigators
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Proportion of patients extubated at the target timing | — |
Secondary
| Measure | Time frame |
|---|---|
| 1)Modified Aldrete score at 1 minute intervals after extubation, and the time until the modified Aldrete score reaches >7 2)Proportion of patients who exhibited body movement before the completion of surgical procedures 3)Simplified higher brain function assessment at operating room discharge (percentage change from preoperative value) 4)Lowest peripheral oxygen saturation until operating room discharge 5)RASS (Richmond Agitation-Sedation Scale) score in the ICU 6)Incidence of delirium up to postoperative day 1 7)Incidence of postoperative nausea and vomiting up to postoperative day 1 8)Patient satisfaction in a postoperative questionnaire 9)Proportion of patients with recall at the time of extubation | — |
Contacts
Public ContactTatsumi Yakushiji
Fukushima Medical University Hospital
Outcome results
None listed