Oral and intestinal environmental changes caused by Bacillus subtilis Reuteri

Research on oral and intestinal environmental changes caused by consumption of yogurt containing Bacillus subtilis Reuteri

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-jRCT1021240063

Enrollment

Registered

2025-03-07

Start date

2025-03-07

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

none

Interventions

Yogurt containing Bacillus subtilis Reuteri was taken once daily and continued for 3 months.

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: (1) Age 65 years or older (at the time of registration) (2) Able to collect saliva and dental plaque from the oral cavity using a Saliva Kid, scaler, or interdental brush (3) Able to collect stool samples (4) Those who consume dairy products on a daily basis (5) Any gender (6) Persons who have given written consent to participate in the research.

Exclusion criteria

Exclusion criteria: (1) Persons with mucosal disease of the oral cavity or intestinal tract (2) Persons who have difficulty collecting saliva, dental plaque, or stool samples (3) Other persons whom the principal investigator or research coordinator determines to be difficult to participate in the research.

Design outcomes

Primary

Measure	Time frame
Changes in oral bacterial flora	—

Secondary

Measure	Time frame
1. Changes in halitosis 2. Changes in stool bacterial flora	—

Contacts

Public ContactHiroyasu Kanetaka

Tohoku University

hiroyasu.kanetaka.e6@tohoku.ac.jp+81-22-717-8415

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026