Patients with high BMI (BMI >25 kg/m2) or weight loss (>20% below ideal body weight or BMI<18.5)
Conditions
Interventions
None listed
Sponsors
Obara Shinju
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: (Study A) 15 patients with high BMI (BMI more than 25) and 15 patients with weight loss (more than 20 per cents below ideal body weight or BMI less than 18.5) undergoing scheduled surgery under general anesthesia using fentanyl (30 patients in total) (Study B) 10 patients with high BMI (BMI more than 25) and 10 patients with weight loss (more than 20 per cents below ideal body weight or BMI less than 18.5) undergoing scheduled surgery under general anesthesia using fentanyl (20 patients in total) Ideal body weight = 22 x height (m2).
Exclusion criteria
Exclusion criteria: 1. Patients who have received fentanyl prior to surgery 2. Patients with allergy to fentanyl 3. Patients with severe hepatic or renal dysfunction or severe hypoalbuminemia 4. Patients undergoing treatment for psychiatric or neurological disorders 5. Patients with severe anemia 6. Patients whose fentanyl dose is not 3 mcg in Study A
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Parameters of the model for predicting fentanyl concentrations. MDPE MDAPE | — |
Secondary
| Measure | Time frame |
|---|---|
| Compare the predictive performance of the models obtained in Study A and in previous studies (Shafer's model, Sibutani's model, Bae's model, and Bienert's model). MDPE and MDAPE The relashionships between above indices and cardiac index | — |
Contacts
Public ContactShinju Obara
Surgical Operation Department, Fukushima Medical University Hospital
Outcome results
None listed