Pseudo Cushing's Syndrome Glucocorticoid , Stress, dexamethasone suppression test
Conditions
Interventions
In patients suspected of having Cushing's syndrome or pseudo-Cushing's syndrome, we perform two loading tests, DEX/CRH and alprazolam tests, in order to confirm the differential ability of these tes
Sponsors
Takayasu Sinobu
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: This study will be conducted in patients with both high basal ACTH and cortisol levels who have a cortisol level of >=3 mcg/dl on a 0.5 mg dexamethasone suppression test or have a midnight cortisol level of >=5 mcg/dl.
Exclusion criteria
Exclusion criteria: Those who are long-term user of steroids should be excluded. In addition, if the blood glucose of patients is consistently above 300 mg/dl, they should be excluded because dexamethasone may exacerbate hyperglycemia.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| ACTH, cortisol, salivary cortisol at midnight after administering alprazolam. Early morning ACTH and cortisol the day after alprazolam oral administration followed by 0.5mg dexamethasone use. ACTH and cortisol 15 minutes later after administering dexamethasone 0.5 mg every 6 hrs for a total of 8 doses, followed by CRH loading. | — |
Secondary
| Measure | Time frame |
|---|---|
| Urinary free cortisol in the early morning after administering alprazolam (spot urine) | — |
Contacts
Public ContactSinobu Takayasu
Hirosaki-university Hospital
Outcome results
None listed