A study to examine differences in inflammation based on blood processing methods during heart surgery

Comparison of Inflammatory Cytokine Levels Between Residual Cardiopulmonary Bypass Circuit Blood and Cell Saver Processed Blood

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

JPRN

Registry ID

JPRN-jRCT1012250013

Enrollment

Registered

2025-06-20

Start date

2025-06-20

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

All conditions requiring surgery with cardiopulmonary bypass

Interventions

none

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Patients aged 20 years or older Patients scheduled to undergo cardiovascular surgery using cardiopulmonary bypass under general anesthesia

Exclusion criteria

Exclusion criteria: Lack of informed consent Emergency surgery Renal dysfunction (serum creatinine more than 2 mg/dL) Judged as inappropriate for participation by the attending anesthesiologist

Design outcomes

Primary

Measure	Time frame
Comparison of inflammatory cytokine levels (IL-6, IL-8, TNF-alfa, IL-10) between residual cardiopulmonary bypass circuit blood and cell saver processed blood	—

Secondary

Measure	Time frame
Changes in red blood cell count, white blood cell count, and hemoglobin concentration before and after cell saver processing Changes in complement factors C3 and C5a concentrations Correlation between cytokine reduction rates and clinical parameters (e.g., cardiopulmonary bypass time) Associations with perioperative variables such as patient background, bleeding volume, transfusion volume, and anesthetic drug usage	—

Measure

Time frame

Changes in red blood cell count, white blood cell count, and hemoglobin concentration before and after cell saver processing Changes in complement factors C3 and C5a concentrations Correlation between cytokine reduction rates and clinical parameters (e.g., cardiopulmonary bypass time) Associations with perioperative variables such as patient background, bleeding volume, transfusion volume, and anesthetic drug usage

—

Contacts

Public ContactYusuke Yoshikawa

Sapporo Medical University, Department of Anesthesiology

y.yoshikawa@sapmed.ac.jp+81-11-688-9663

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026