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Is there a difference in the incidence of postpartum depression depending on the type of sedative used after delivery by cesarean section?

Can sedatives after caesarean delivery prevent postpartum depression?

Status
Recruiting
Phases
Unknown
Study type
Interventional
Source
JPRN
Registry ID
JPRN-jRCT1011250009
Enrollment
105
Registered
2025-05-30
Start date
2025-05-20
Completion date
Unknown
Last updated
2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Cesarean section Cesarean section

Interventions

Intervention begins when the onset of labor pains occurs. Propofol is administered using a TCI (Targeted Controlled Infusion
TCI) pump, and the blood concentration is gradually increased, with the effect-site concentration set as the target blood concentration when sufficient sedation is achieved. Dexmedetomidine is admini
D000771

Sponsors

Kii Natsumi
Lead Sponsor

Eligibility

Sex/Gender
Female

Inclusion criteria

Inclusion criteria: Patients aged 18 years or older who are undergoing Caesarean section after the 38th week of pregnancy and will receive sedatives after delivery

Exclusion criteria

Exclusion criteria: Patients under 18 years of age, under 37 weeks pregnant, patients with a history of allergies to propofol, dexmedetomidine, or fentanyl, patients with contraindications for propofol or dexmedetomidine, or patients who did not give their consent.

Design outcomes

Primary

MeasureTime frame
The endpoint was recovery status from day 1 to day 5 after surgery using the postpartum recovery score ObsQoR.

Secondary

MeasureTime frame
Screening for the onset of postpartum depression was performed using the Edinburg Postnatal Depression Scale (EPDS), a postpartum depression scale. BDNF levels before anesthesia induction after entering the operating room and on the first postoperative day, additional postoperative analgesic dosage, time to mobilization after surgery, length of hospital stay, pain score (Numeric Rating Scale; NRS), and the presence or absence of complications were also assessed.

Contacts

Public ContactNatsumi Kii

Sapporo Medical University

aboutdesouffle_jean@hotmail.com+81-11-611-2111

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026