Patients after induction of general anesthesia
Conditions
Interventions
Patients will be randomly assigned to one of two groups: the remimazolam group and the propofol group. Allocation will be by random assignment using Muzinwali. The allocation adjustment factors will b
remimazolam, propofol, mean circulatory filling pressure
Sponsors
Yamakage Michiaki
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1) Patients scheduled to undergo standby surgery under general anesthesia in the operating room of Sapporo Medical University Hospital. 2) The patient is scheduled to undergo arterial pressure monitoring using an arterial line under general anesthesia. 3) Adults aged 20 years or older at the time of surgery. 4) The patient's preoperative condition should be ASA-PS (American Society of Anesthesiologists Physical Status) 1-2 and in good general condition.
Exclusion criteria
Exclusion criteria: (1) Patients with contraindications to propofol or remimazolam (2) Patients who are allergic to propofol, remimazolam, midazolam, or flumazenil. (3) Patients who are allergic to propofol, remimazolam, midazolam, or flumazenil. (4) Patients with severe hepatic or renal dysfunction that may affect drug metabolism. (5) Patients with severe hepatic or renal dysfunction that may affect drug metabolism (5) Other patients who are judged inappropriate for participation in this study by the principal investigators and sub-investigators
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Pmcf values before induction of general anesthesia, immediately after induction, 30 minutes after induction, and after infusion load | — |
Secondary
| Measure | Time frame |
|---|---|
| Blood pressure, pulse rate, oxygen saturation (SpO2), body temperature, cardiac output (CO), single cardiac output (SV), cardiac coefficient of index (CCI), body vascular resistance (SVR), blood gas analysis, and bispectral index (BIS) values before, immediately after, 30 minutes after induction, and after infusion load Total dose of remimazolam and propofol up to the end of infusion load and up to the end of anesthesia Total dose of fentanyl and remifentanil up to the end of infusion load and up to the end of anesthesia Patient background (age, gender, weight, ASA-PS, underlying disease, and medications) Incidence of adverse events in the 24-hour postoperative period (hypoxic events (SpO2<92%), ischemic heart disease, stroke, nausea and vomiting, and number of antiemetic medications used) | — |
Contacts
Public ContactTomoki Hirahata
Department of Anesthesiology, Sapporo Medical University School of Medicine
Outcome results
None listed